Reema A. Al-Eryani, Ghada A. El-Baz, Wael M. Abd-Alkhalek, Essam M. Abd-Allah And Mohamed Sherif M. Salah El-Din,

ABSTRACT
Aim Of The Study: To Study The Variations In Some Salivary Parameters (pH, Ca2+, SIgA, Lysozyme) And Their Influence On Dental Caries Status In Egyptian And Yemenis Asthmatic Children. Subjects And Methods: This Study Was Carried Out On Two Hundred Children Of Both Sexes With Age Ranged From 6-10 Years. The Cases Were Divided Into Two Main Groups; One Hundred Children From Egypt And One Hundred Children From Yemen. Each Group Was Subdivided Into Two Subgroups; Fifty Children Asthmatic And Fifty Children Healthy. Dental Caries Was Assessed For Each Child According To WHO Criteria (1997) For Detection Of Caries Using Defs For Primary Dentition. Saliva Samples Were Collected From Each Child To Measure: PH, Ca2+, SIgA, And Lysozyme. The Correlation Between Different Salivary Parameters And Dental Caries In Primary Dentition Was Evaluated.

Results: Asthmatic Children Showed No Significant Differences In All Studied Variables Between Egyptians And Yemenis. While For Healthy Children, Egyptians Showed Statistically Significant Higher Mean PH Level And Defs Score And Lower Ca2+ And Lysozyme Levels Than Yemeni Children. In Comparing Between Asthmatic And Healthy Children, Egyptian Asthmatic Children Showed Statistically Significant Lower Mean PH Level And Higher Mean Ca2+, SIgA, And Lysozyme Levels Than Healthy Children. Yemeni Asthmatic Children Showed Statistically Significant Higher Mean PH And Lysozyme Levels Than Healthy Children. Concerning Defs, All In Egyptian Or Yemeni Children As Well As The Whole Sample; Asthmatics Showed Lower Mean Defs Scores Than Healthy Children. There Was A Statistically Significant Negative Correlation Between Defs Score And Lysozyme Level In Egyptian Asthmatics. Egyptian Healthy Showed A Negative Correlation Between Defs Score And PH Level And Positive Correlation With Ca2+ Level. Concerning Yemeni Asthmatic Group, There Was A Statistically Significant Positive Correlation Between Defs Score And SIgA And Negative Correlation Between Defs Score And Lysozyme. While For Yemeni Healthy Children, There Was A Statistically Significant Positive Correlation Between Defs Score And PH Level. ROC Curve Analysis Showed That Saliva Samples Of Children With SIgA Above 271.0 �g/ml And 304.0 �g/ml For Egyptian And Yemenis Respectively, Can Be Suspected For Asthma With Accuracy Of 68% And 64% In Both Groups Respectively. Conclusion: Salivary Analysis Revealed An Overall Altered Salivary Composition In Children With Asthma, And Suggesting Salivary Analysis As An Additional Diagnostic Tool For Allergic Diseases.